Multiple Pathways for Cationic Amino Acid Transport in Rat Seminiferous Tubule Cells1

Multiple pathways for cationic amino acid transport in rat thyroid epithelial cell line PC Cl3.

Information regarding cationic amino acid transport systems in thyroid is limited to Northern blot detection of y(+)LAT1 mRNA in the mouse. This study investigated cationic amino acid transport in PC cell line clone 3 (PC Cl3 cells), a thyroid follicular cell line derived from a normal Fisher rat retaining many features of normal differentiated follicular thyroid cells. We provide evidence that...

Cationic and anionic amino acid transport studies in rat red blood cells.

The transport of L-proline, L-lysine and L-glutamate in rat red blood cells has been studied. L-proline and L-lysine uptake were Na(+)-independent. When the concentration dependence was studied both showed a non-saturable uptake assimilable to a difussion-like process, with high Kd values (0.718 and 0.191 min-1 for L-proline and L-lysine respectively). Rat red blood cells showed high impermeabi...

Cationic Amino Acid Transporters

We have identified the third member of a family of cationic amino acid transporters in lipopolysaccharidestimulated murine macrophages. The deduced amino acid sequence of this transporter is the same as MCAT-2 (mouse cationic amino acid transporter-Z), the low affinity transporter expressed in hepatocytes, except for a stretch of 41 amino acids that connects the eighth and ninth membrane-spanni...

Expression of Cationic Amino Acid

Cationic amino acid transport in the rabbit reticulocyte. Na+-dependent inhibition of Na+-independent transport.

A transport system for cationic amino acids has been described for the rabbit reticulocyte. This system appears neither concentrative nor energy-dependent. At high levels, several neutral amino acids with large apolar side chains inhibit uptake by it; furthermore, the presence of external leucine accelerates lysine exodus from the cell. These effects do not, however, arise from an interaction b...